The Melbourne singer-songwriter capped an incredible year at the Sydney Entertainment Centre ceremony on Thursday, also wining the awards for best pop release and Australian live act.
"Gosh I've been standing up here a lot," he said as he accepted the final award of the night, for best album.
"There are a bunch of fantastic albums, especially by Australian artists, that I fell in love with this year ... so keep listening to records, keep buying records."
Taking his total ARIA haul to 10, Gotye now sits alongside John Farnham, Diesel and Alex Lloyd as the most decorated winners of the best male title with three apiece.
It's the second year in a row that Gotye - aka Wally de Backer - has won the best male artist award.
He shared the spotlight with Kimbra, his collaborator on the international smash Somebody That I Used To Know, who reclaimed her title as best female artist for a second year.
The quirky Kiwi, who now lives in Melbourne, stunned the black carpet in a flamingo-inspired outfit, then stunned the auditorium with her performance of Settle Down.
"This means a lot to me and these things are brutal... What a whirlwind year it's been and what an amazing way to top it off to be acknowledged for this record I started making in Melbourne at 17," she said in accepting her award from British actor Russell Brand.
Melbourne band The Temper Trap also continued where they left off by taking home the ARIA for best group - an award they also won in 2010.
Their self-titled No.1 album also picked up the award for best rock album.
Rapper 360 won the breakthrough artist of the year award while his idols Hilltop Hoods claimed urban album of the year.
Seven time ARIA winner Missy Higgins added another trophy to her collection with the award for best adult contemporary.
Best independent release went to indie favourites The Jezabels for their debut album Prisoner.
Gotye was presented with his award by American country-pop superstar Taylor Swift, who also performed on the night.
"There's nothing like the Australian fans and you guys have been unbelievable to me - and I've also had an amazing time enjoying the Australian music tonight," Swift said.
Paul Kelly and Peter Garrett inducted Aboriginal Music icons Yothu Yindi into the ARIA Hall of Fame.
The band were joined on stage by Jessica Mauboy, Dan Sultan, Paul Kelly and Andrew Farriss to perform the international hit Treaty.
Yothu Yindi used their ARIA induction on Thursday to call for the recognition of indigenous Australians in the constitution.
"As musicians, recognition from our peers is important to us," Yothu Yindi frontman Mandawuy Yunupingu said.
"As Aboriginal Australians, recognition from our constitution is even more important."
And The Wiggles took home their 11th ARIA, winning the best children's alum.